Preparation,characterization, and in vitro release of folic acid-conjugated chitosan nanoparticles loaded with methotrexate for targeted delivery |
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Authors: | Email author" target="_blank">Jingou?JiEmail author Danjun?Wu Li?Liu Jida?Chen Yi?Xu |
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Affiliation: | (1) Chongqing, China |
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Abstract: | To reduce the toxicity of methotrexate (MTX) and increase the targeting of nanoparticles, the MTX-loaded chitosan (CS) covalently
bonded with folic acid (FA) nanoparticles were prepared, and sodium tripolyphosphate was used as the cross-linking agent.
FA was successfully conjugated to CS confirmed by 1H-NMR and Fourier transform infrared spectrometer (FT-IR). The prepared FA–CS nanoparticles were characterized by FT-IR spectroscopy
to confirm the cross-linking reaction between FA–CS and cross-linking agent. X-ray diffraction was performed to reveal the
crystalline nature of the drug after encapsulation. The average diameters of the nanoparticles ranged from 293.9 ± 24.2 to
401.5 ± 20.4 nm with a narrow particle size distribution. In vitro release pattern in phosphate buffer saline (pH 6.8) indicated
that the characteristics of the MTX-loaded nanoparticles appeared to have an initial burst effect and followed by a slow,
sustained drug release. FA or low molecular weight FA conjugate fragments were also released from the nanoparticles, which
might have potential to reduce toxic effects of MTX within the body. |
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Keywords: | |
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