Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices |
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Authors: | B Nicol DG Lambert DJ Rowbotham E Okuda-Ashitaka S Ito D Smart AT McKnight |
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Affiliation: | University Department of Anaesthesia, Leicester Royal Infirmary, UK. |
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Abstract: | We have examined the effects of the recently described heptadecapeptide nocistatin on K+-evoked glutamate release from rat cerebrocortical slices in vitro. In vivo, nocistatin reverses the action of nociceptin. Nocistatin (100 nM, n = 7) did not inhibit K+-evoked glutamate release alone. Nociceptin (100 nM) inhibited glutamate release by 51.7 +/- 8.3% (P < 0.05, n = 6) and this was fully reversed by nocistatin (100 nM). Nocistatin also appears to be an antagonist of nociceptin action in vitro. |
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