微气孔球扁药通孔结构的制备

采用改变药型、以不同盐溶液为内水相、化学发泡法3种方法制备微气孔球扁药。利用测量堆积密度和扫描电镜观察药粒剖面结构等手段表征孔隙率和孔结构。结果表明,将球状药改型为球扁状药,药粒中大孔和小孔均为通孔结构。当内水相盐浓度高于0.20g/cm3时,药粒中大孔和小孔均由闭孔结构向通孔结构转变。采用化学发泡法制备微气孔球扁药,小孔均为闭孔结构,不同驱溶量发泡对大孔结构有很大影响,驱溶量为29%时,发泡制备的球扁药中大孔为通孔结构。实验采用的3种方法均能有效控制微气孔球扁药中的通孔结构。

Preparation of Through Hole Structure in Micro-pores Oblate Spherical Powder

The micro-pores oblate spherical powder(MOSP) was prepared by changing the shape of MOSP,using different concentration of salt solution as internal water phase,and chemical foaming.The porosity and hole structure of MOSP were characterized by measuring bulk density and viewing section structure by SEM.The results indicate that by changing spherical powder to oblate spherical powder,both small and big hole in MOSP become through hole structure.The structure of small and big hole changes from closed structure to through structure as the concentration of salt solution in the internal water phase is higher than 0.20 g/cm3.All of the small hole structure are closed in MOSP by chemical foaming,different amounts of solvent evaporated in chemical foaming has a great impact on big hole structure,most of the big hole are through structure when the solvent is evaporated 29% of total solvent.The three ways which were used in the experiment can effectively control the through structure in MOSP.