非平衡循环吸附色谱分离研究

引言制备或大型液相色谱因在温和条件下具有高分辨分离能力且操作简单而广泛应用于药物、生物化学品和碳氢化合物等的分离和高纯化．其应用的范围和规模正在不断发展．然而，传统的吸附色谱因其吸附剂利用率低，生产效率低．为克服这一缺陷，Wankat，Barker和Ganetsos以及Ruthven和Ching等人比较了各种逆流、错流和模拟移动床色谱分离技术和原理，提出各种柱组合分离的方法．模拟移动床色谱能获得较高生产效率，但其设备和操作较复杂，一定程度上限制了它的应用．循环色谱是一种新颖的分离技术，这一概念最早是由Bombaugh和Biesenberger…

NON-EQUILIBRIUM CYCLING LIQUID ADSORPTION CHROMATOGRAPHY

A non-linear and non-equilibrium model of cycling chromatography was established．Computer simulation and experiment of the process of cycling chromatography showed that the productionrate of cycling chromatography was higher than that of conventional chromatography method The production rate of the cycling chromatographic separation increased with the increase of the cycling number. The use of the cycling chromatography technique would improve apparently improve the production rate if the solid／liquid interface mass transfer resistance was large or the apparent selectivity coefficients of adsorbants were small.The elution curves calculated by the model of non-linear and nonequilibrium cycling chromatography, were in good agreement with experimental elution curves of chromatography while the elution curves calculated by the model of the equilibrium cycling chromatography deviated from the experimental elution curves of chromatography.