Study on rosmarinic acid separation by synergic extraction |
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| Authors: | L Kloetzer A S Bompa A C Blaga A I Galaction D Ca?caval |
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| Affiliation: | 1. Faculty of Chemical Engineering and Environmental Protection “Cristofor Simionescu”, Department of Biochemical Engineering, “Gheorghe Asachi” Technical University of Iasi, Iasi, Romania;2. Faculty of Medical Bioengineering, Department of Biomedical Science, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania |
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| Abstract: | Separation of rosmarinic acid by synergic reactive extraction using a mixture of two extractants (one of aminic and one of basic type) dissolved in solvents with different polarities has been studied. By analysing the influences of the main factors (organic phase polarity, extractant concentration in the mixture) on the synergic effect, the most important synergic effect (CS = 10.89) was found to correspond to the extractants mixture containing 5 g/l D2EHPA and 5 g/l Amberlite LA-2 dissolved in n-heptane. In this system the extraction constant reached the maximum value of 6.78 l2/mol2. |
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| Keywords: | Rosmarinic acid Amberlite LA-2 di(2-ethylhexyl) phosphoric acid extraction constant synergic coefficient |
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