| LC-MS/MS测定肠衣中7种大环内酯类抗生素残留量 |
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| 引用本文： | 林维宣,陈溪,张宁,董伟峰,王秋艳,赵景红. LC-MS/MS测定肠衣中7种大环内酯类抗生素残留量[J]. 食品研究与开发, 2012, 33(9): 123-128 |
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| 作者姓名： | 林维宣 陈溪 张宁 董伟峰 王秋艳 赵景红 |
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| 作者单位： | 1. 辽宁出入境检验检疫局,辽宁大连,116001
2. 大连出入境检验检疫局,辽宁大连,116001 |
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| 基金项目： | 国家“十一·五国家科技支撑计划”课题“动物源食品中兽药残留量的系统分析方法研究”子课题(2006BAK02A08-9-3) |
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| 摘 要： | 建立猪肠衣中螺旋霉素、替米考星、竹桃霉素、泰乐菌素、红霉素、罗红霉素、交沙霉素等7种大环内酯类抗生素残留量的液相色谱-串联质谱测定方法(LC/MS/MS).样品用甲醇提取,Oasis( HLB)固相萃取柱净化,液相色谱-串联质谱测定,外标峰面积法定量.方法的回收率范围为70.9 ％～98.4％；相对标准偏差5.8 ％～17.8％,7种大环内酯类抗生素的检出限均为20 μg/kg.
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| 关 键 词： | 大环内酯类抗生素 猪肠衣 液相色谱-串联质谱 |
Determination of 7 Kinds of Macrolides Antibiotics Residues in Casing by LC-MS/MS |
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| LIN Wei-xuan , CHEN Xi , ZHANG Ning , DONG Wei-feng , WANG Qiu-yan , ZHAO Jing-hong. Determination of 7 Kinds of Macrolides Antibiotics Residues in Casing by LC-MS/MS[J]. Food Research and Developent, 2012, 33(9): 123-128 |
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| Authors: | LIN Wei-xuan CHEN Xi ZHANG Ning DONG Wei-feng WANG Qiu-yan ZHAO Jing-hong |
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| Affiliation: | 1(1.Liaoning Entry-Exit Inspection and Quarantine Bureau,Dalian 116001,Liaoning,China;2.Dalian Entry-Exit Inspection and Quarantine Bureau,Dalian 116001,Liaoning,China) |
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| Abstract: | A multiresidue method for the detection of 7 macrolides antibiotics(spiramycin,tilmicosin,leandomycin,tylosin,erythromycin,roxithromycin and josamycin) in pig casing is presented.The method use Methanol during the extraction procedure and cleanup step over a Oasis(HLB) SPE cartridge.The analytes are separated and detected by liquid chromatography-electrospray ionization tandem mass spectrometry(LC/MS/MS) using external standard method.The recoveries for all 7 macrolides antibiotics was 70.9 %-98.4 %.the relative standard deviation(RSD) of them was 5.8 %-17.8 %.The method limit of detection were 20 μg/kg for all macrolides antibiotics. |
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| Keywords: | macrolides antibiotics pig casing LC-MS/MS |
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