| (R)-(-)-α-对氯苯基异戊酸消旋利用的研究 |
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| 引用本文： | 韩邦友,朱红军,徐守林,欧阳平凯. (R)-(-)-α-对氯苯基异戊酸消旋利用的研究[J]. 农药, 2004, 43(9): 397-399 |
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| 作者姓名： | 韩邦友 朱红军 徐守林 欧阳平凯 |
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| 作者单位： | 南京工业大学,南京,210009;江苏快达农化股份有限公司,江苏,南通,226401;南京工业大学,南京,210009;江苏快达农化股份有限公司,江苏,南通,226401 |
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| 摘 要： | (R)-(-)-a-对氯苯基异戊酸为光学活性菊酯类杀虫剂顺式氰戊菊酯生产中产生的无效旋光异构体。本文研究了它消旋利用的工艺,在NaOH作用下在DMSO溶剂中回流反应4～6h可消旋化得到(±)-对氯苯基异戊酸,其产品含量大于98%,比旋光度=0。该消旋产物经过拆分得到的(S)- 对氯苯基异戊酸完全适用于(S,S)- 氰戊菊酯的合成。
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| 关 键 词： | (R)-(-)-α-对氯苯基异戊酸 消旋 拆分 |
| 文章编号： | 1006-0413(2004)09-397-03 |
Racemization of (R)-2-(4''''-Chlorophenyl)-3-methylbutyricacid and its Application on Synthesis of (S,S)-esfenvalerate |
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| HAN Bang-You,,ZHU Hong-Jun,XU Shou-Ling,OU-YANG Ping-Kai. Racemization of (R)-2-(4''''-Chlorophenyl)-3-methylbutyricacid and its Application on Synthesis of (S,S)-esfenvalerate[J]. Pesticides, 2004, 43(9): 397-399 |
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| Authors: | HAN Bang-You ZHU Hong-Jun XU Shou-Ling OU-YANG Ping-Kai |
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| Affiliation: | HAN Bang-You1,2,ZHU Hong-Jun1,XU Shou-Ling2,OU-YANG Ping-Kai1 |
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| Abstract: | R)-(-)-2-(4-chlorophenyl)-3-methylbutyricacid is an ineffective isomer produced by resolutionduring the manufacture of esfenvalerate. But it could be racemized by NaOH in DMSO under refluxing, theracemate was produced in about 98% yield, =0. The (?-2-(4-chlorophenyl)-3-methylbutyricacid could beseparated and applied in the synthesis of (S, S)-esfenvalerate. |
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| Keywords: | R)-(-)-2-(4-chlorophenyl)-3-methylbutyricacid racemization resolution |
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