Synthesis and radioprotective activity of new organosilicon and germanium compounds |
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Authors: | Rima G Satgé J Dagiral R Lion C Fatome M Roman V Laval J D |
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Affiliation: | Laboratoire d′Hétérochimie Fondamentale et Appliquée UPRES-A 5069 du CNRS Université Paul Sabatier, 118 route de Narbonne Toulouse Cedex 31062 France. |
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Abstract: | Silathiazolidine and metalladithioacetals (M = Si, Ge) have been prepared by the interaction of dialkyldichloro- or bis(diethylamino)dialkylsilanes and -germanes with 3-N-(2- thioethyl)]amino-propanamide (WR-2529) and 1-thioethyl-2-(1-naphtylmethyl)]-2- imidazoline. The study of these compounds in the field of chemical radioprotection has shown a notable decrease in the toxicity and a rather large increase in the radioprotective activity of these new derivatives in comparison with the starting organic compounds. |
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