Functional acrylic acid as stabilizer for synthesis of smart hydrogel particles containing a magnetic Fe3O4 core |
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Authors: | Feng-Yi Chou Chao-Ming Shih Meng-Chao Tsai Wen-Yen Chiu Shingjiang Jessie Lue |
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Affiliation: | 1. Department of Chemical and Materials Engineering, Chang Gung University, 259 Wen-Hwa First Road, Kwei-Shan, Taoyuan 333, Taiwan;2. Department of Chemical Engineering, National Taiwan University, 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan |
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Abstract: | This paper reports a novel method to synthesize magnetic, stimuli-sensitive latex nanoparticles made with magnetite/poly(N-isopropylacrylamide-co-acrylic acid) (Fe3O4/P(NIPAAm-co-AAc)). To form a stabilized suspended core, iron oxide (Fe3O4) was functionalized with AAc such that further polymerization with NIPAAm and AAc monomers could occur. The P(NIPAAm-co-AAc) shell layer exhibited thermosensitive properties. The inclusion of Fe3O4 into the latex nanoparticles was confirmed using transmission electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction spectroscopy, thermogravimetric analyzer (TGA), and superconducting quantum interference device magnetometer. The NIP–(AAc2.6–Fe) latex nanoparticles contained 2.25% Fe3O4 (by weight), as determined by TGA analysis. The particle diameters measured approximately 160–240 nm with a lower critical solution temperature of 35 °C. These novel magnetic stimuli-responsive latex nanoparticles have potential applications in numerous fields, such as catalyst supports, protein immobilization, cancer therapy, target drug delivery systems, and other biomedical applications. |
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