Freeze-Dried Preparations of Ketoprofen and Heptakis- (2, 6-O-Dimethyl) -β-Cyclodextrin |
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| Authors: | O. Funk L. Schwabe K. -H. Fr ming |
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| Affiliation: | a Institut fur Pharmazie der Freien Universitat Berlin Kelchstraβe, Berlin, Germany |
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| Abstract: | ABSTRACT
The purpose of this study was to examine the inclusion formation in freeze-dried preparations of ketoprofen and heptakis-(2,6-0-dimethyl)-β-cyclodextrin. The products obtained were amorphous mixtures of the two components. X-ray diffractography, differential scanning calorimetry, 13C-CPMAS-NMR spectroscopy and thermofractography did not give any proof of an inclusion of ketoprofen in the cyclodextrin cavity. |
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