Optimization of a Granulation Procedure for a Hydrophilic Matrix Tablet Using Experimental Design |
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| Authors: | S. Bouckaert D. L. Massart Massart J. P. Remon |
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| Affiliation: | a Laboratory of Pharmaceutical Technology, University of Gent, Gent, Begliumb Pharamceutical Institute, Vrije Universiteit Brussel (VUB), Brussels, Belgiumc Department of Chemistry, University of Bergen, Bergen, Norway |
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| Abstract: | An experimental design was used in order to optimize a granulation procedure in a high-shear mixer for a hydrophilic matrix tablet formulation. The parameters tested were the amount of water in the hydroalcoholic granulation liquid, the amount of granulation liquid, and the massing time. The amount of granulation liquid was the most important parameter, followed by the amount of water in the granulation liquid. The influence of the massing time was negligible. A granule with a friability below 20% was obtained. |
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