| 铅对大鼠体内锌、铜、铁和锰含量的影响 |
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| 引用本文： | 王雪飞,张杰,张智勇,刘年庆,赵保路,柴之芳. 铅对大鼠体内锌、铜、铁和锰含量的影响[J]. 核化学与放射化学, 2004, 26(4): 215-219 |
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| 作者姓名： | 王雪飞 张杰 张智勇 刘年庆 赵保路 柴之芳 |
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| 作者单位： | 中国科学院,高能物理研究所,核分析技术开放实验室,北京,100039;中国科学院,生物物理研究所,北京,100101 |
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| 基金项目： | 自然科学基金资助项目(10175077)，中国科学院重要方向性创新资助项目(KJCX N01) |
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| 摘 要： | 雄性SD大鼠腹腔注射乙酸铅水溶液染毒25d后,通过饮水服用二巯基丁二酸(DMSA)10d。用X射线荧光法分析大脑、小脑、海马以及肝、肾和血中铅、锌、铜、铁和锰含量。结果表明,大脑中铅的质量分数高于小脑和海马;摄入铅后的海马中铜、铁和锰的质量分数升高,小脑中锰的质量分数明显上升(p<0.05);肾脏中的铜、铁、锌均显著降低,血液中锌和铜下降(p<0.05);DMSA能有效清除动物体内的铅,部分缓解铅造成的微量元素失衡。
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| 关 键 词： | 铅中毒 微量元素 DMSA |
| 文章编号： | 0253-9950(2004)04-0215-05 |
| 修稿时间： | 2004-01-05 |
Effect of Lead on Zn, Cu, Fe and Mn Content in Rats |
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| WANG Xue-fei,ZHANG Jie,ZHANG Zhi-yong,LIU Nian-qing,ZHAO Bao-lu,CHAI Zhi-fang . Laboratory of Nuclear Analytical Techniques. Effect of Lead on Zn, Cu, Fe and Mn Content in Rats[J]. Journal of Nuclear and Radiochemistry, 2004, 26(4): 215-219 |
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| Authors: | WANG Xue-fei ZHANG Jie ZHANG Zhi-yong LIU Nian-qing ZHAO Bao-lu CHAI Zhi-fang . Laboratory of Nuclear Analytical Techniques |
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| Affiliation: | WANG Xue-fei~1, ZHANG Jie~2, ZHANG Zhi-yong~1, LIU Nian-qing~1, ZHAO Bao-lu~2, CHAI Zhi-fang~1 1. Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, the Chinese Academy of Sciences, Beijing 100039, China; 2. Center for Brain and Cognitive Sciences, Institute of Biophysics, the Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract: | Male SD rats are treated Pb by ip for 25 d, and then fed DMSA through drinking water for 10 d. The levels of lead and several other metal elements in cerebrum, cerebella, hippocampus, liver, kidneys and blood of the rats are measured by X-ray fluorescence method. The lead concentration in cerebrum is higher than that in cerebella and hippocampus. After exposure to lead, Cu, Fe and Mn levels of hippocampus are increased, and Mn in cerebella is decreased significantly (p<0.05), meanwhile Cu, Fe and Zn in kidneys are decreased, and blood Zn and Cu increased (p<0.05). The results show that DMSA could effectively chelate the lead in rat body, the effect of lead on trace elements could be partially eliminated. |
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| Keywords: | lead poisoning trace element DMSA |
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