| 聚乳酸组织工程支架在SBF溶液中的降解和矿化性能 |
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| 引用本文： | 葛建华,王迎军,郑裕东. 聚乳酸组织工程支架在SBF溶液中的降解和矿化性能[J]. 材料科学与工程学报, 2011, 0(1): 90-93 |
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| 作者姓名： | 葛建华 王迎军 郑裕东 |
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| 作者单位： | 山东大学材料学院;山东大学材料液固结构演变与加工教育部重点实验室;华南理工大学材料学院;北京科技大学材料学院 |
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| 摘 要： | 本文利用扫描电镜、X射线衍射仪以及红外漫反射仪,并通过对聚乳酸组织工程支架在模拟体液(SBF)中的失重率、分子量以及模拟体液pH值变化的测试,系统地研究了聚乳酸组织工程支架在模拟体液中的降解和矿化性能。结果发现:在模拟体液中,随着时间的增长,聚乳酸组织工程支架的分子量不断下降;但是其重量并不随着时间的增长而减小,而是有升有降。X-射线衍射图谱和FTIR漫反射图谱研究表明,在模拟体液中,聚乳酸组织工程支架的表面有磷灰石沉积物出现。
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| 关 键 词： | 聚乳酸 组织工程支架 SBF溶液 降解 矿化 |
Degradable Performance and Bio-mineralization Function of Poly(lactic acid) Tissue Engineering Scaffold in SBF |
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| GE Jian-hua,WANG Ying-jun,ZHENG Yu-dong. Degradable Performance and Bio-mineralization Function of Poly(lactic acid) Tissue Engineering Scaffold in SBF[J]. Journal of Materials Science and Engineering, 2011, 0(1): 90-93 |
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| Authors: | GE Jian-hua WANG Ying-jun ZHENG Yu-dong |
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| Affiliation: | 1.School of Materials Science and Engineering,Shandong University,Jinan 250061,China;2.School of Materials Science and Engineering,South China University of Technology,Guangzhou 510640,China;3.Materials Science and Engineering School,University of Science and Technology Beijing,Beijing 100083,China;4.Key Laboratory for Liquid-solid Structural Evolution & Processing of Materials(Ministry of Education),Shandong University,Jinan 250061,China) |
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| Abstract: | The degradable performance and bio-mineralization function of poly(lactic acid) tissue engineering scaffolds in simulated body fluid(SBF) were systematically studied by measuring the pH value of SBF,the rates of weight lost of scaffolds,the molecular weight change of materials,and characterization of the scaffolds was carried out by scanning electron microscopy(SEM),X-ray diffractometry(XRD) and Fourier transform infrared(FTIR) spectroscopy.It was found in SBF that the molecular weight of scaffolds decreased with the prolongation of time.However,the weight of scaffolds did not always decrease with the prolongation of time.The XRD and FTIR showed that there was the deposition of bone-like carbonate hydroxyl apatite on the surfaces of the scaffolds. |
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| Keywords: | poly(lactic acid) tissue engineering scaffold simulated body fluid degradation mineralization |
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