组成性雄烷受体遗传多态性与个体化治疗

组成性雄烷受体（constitutive androstane receptor, CAR）通过调控细胞色素P450（cytochromeP450, CYP450）等一相代谢酶、UDP-葡萄糖醛酸转移酶（UDP-glucuronosyltransferases, UGTs）等二相代谢酶及多药耐药相关蛋白（multidrug resistance-associated protein, MRP）等药物转运体等代谢相关基因，对外源性药物代谢及维系体内血糖、血脂、胆红素等多种内源性物质的代谢平衡发挥重要作用。作为体内物质代谢的枢纽，CAR直接影响了代谢性疾病的发生以及多种药物的疗效，对其多态性的研究有利于从基因层面解释个体化治疗的差异性，预见相关疾病的发生进展。本文拟就近几年来CAR单核苷酸多态性影响物质代谢的相关研究作一综述，探究CAR多态性与物质代谢的相关性，为临床上疾病的发生及药物用法用量的提前预测提供科学依据。

Relevance of CAR genetic polymorphism and individual therapy

Regulating phase I and II enzyme, drug transporters and constitutive androstane receptor (CAR) play an important role in dug metabolism and keeping balance on the levels of glucose, lipids and hormone in serum. As a hub of material metabolism within body, CAR can affect the efficacy of various drugs and be involved in many common metabolic diseases. Studying its polymorphism is referential for explaining the individual difference genetically and predicting the occurrence and development of diseases. This review focuses on the correlation between the CAR polymorphism and metabolic, which provides evidence for predicting the development of disease and choosing clinical drug dosage.