氟尿嘧啶外涂与干扰素注射联合液氮冷冻治疗多发性跖疣的疗效及对患者免疫功能的影响

目的:探讨氟尿嘧啶外涂与干扰素注射联合液氮冷冻治疗多发性跖疣的疗效及对患者免疫功能的影响。方法:将78例多发性跖疣患者分为两组，每组39例。对照组采用液氮冷冻联合氟尿嘧啶外涂。观察组在对照组基础上，给予注射干扰素。观察两组皮损变化情况。对比两组治疗前后T淋巴细胞水平变化。采用DLQL法评估患者生存质量变化。 结果: 观察组的疗效显著优于对照组，差异有统计学意义（Z=2.312，P<0.05）；观察组治疗后CD3、CD4、CD4/CD8显著升高（P<0.05）；治疗后，观察组的CD3、CD4、CD4/CD8显著高于对照组，差异有统计学意义（P<0.05）；观察组治疗后皮损评分、DLQL评分显著降低（P<0.05）；治疗后，观察组的皮损评分、DLQL评分显著低于对照组，差异有统计学意义（P<0.05）。结论:氟尿嘧啶外涂与干扰素注射联合液氮冷冻治疗多发性跖疣的疗效确切，能显著提高患者免疫功能。

Therapeutic effect of fluorouracil coated with interferon injection combined with liquid nitrogen cryotherapy in the treatment of verruca plantaris and influence on immune function in patients

AIM: To evaluate the clinical efficacy of fluorouracil coated with interferon injection combined with liquid nitrogen cryotherapy in the treatment of verruca plantaris and influence on immune function in patients. METHODS: 78 cases of verruca plantaris were divided into two groups, each group of 39 cases. In the control group, the liquid nitrogen was used as the control group, and on the basis of the control group, the observation group was given intramuscular interferon. Changes of skin lesions in the two groups were observed. Changes of T lymphocyte levels before and after treatment were compared between the two groups. DLQL method was used to assess the quality of life of patients. RESULTS: The curative effect of the observation group was significantly better than that of the control group. The difference was statistically significant (Z=2.312,P<0.05). CD3, CD4, CD4/CD8 of observation group were significantly increased after treatment (P<0.05). After treatment, the CD3, CD4 and CD4/CD8 in the observation group were significantly higher than those in the control group. The difference was statistically significant (P<0.05). After treatment, the skin lesion score and DLQL score of the observation group were significantly lower (P<0.05) than that of the control group. After treatment, the skin lesion score and DLQL score of the observation group were significantly lower than that of the control group. The difference was statistically significant (P<0.05). CONCLUSION: The therapeutic effect of fluorouracil coated with interferon injection combined with liquid nitrogen cryotherapy in the treatment of verruca plantaris is effective, and can significantly improve the immune function of patients.