肝X受体的基因多态性与代谢类疾病的相关性

肝X受体（liver X receptor,LXR）是人体内一种重要的核受体，为配体依赖性蛋白。LXR作为体内激素和营养信号的整合者，主要通过调控脂质和糖类等途径调节机体新陈代谢，参与Ⅱ型糖尿病、肥胖、心血管疾病、高脂血症等多种常见代谢疾病的发生发展。有研究证明，多个LXR基因多态性位点与代谢类疾病发生发展密切相关。研究LXR参与代谢性疾病的病理机制、探究LXR基因多态性与代谢性疾病的相关性,有利于从基因层面检测和评估代谢类疾病的发生风险，从而实现早期发现和预防该疾病的发生，提高代谢性疾病患者的生存质量，延长生存期。本文拟就近五年LXR参与代谢途径和其基因多态性与代谢性疾病的相关性做一综述。

Relativity between the gene polymorphisms of LXR and metabolic syndrome

Liver X receptor(LXR) is an important nuclear receptor in the body, which is a ligand-dependent protein. LXR is an integrator of hormonal and nutritional signal mediating changes to metabolic pathways of lipid and glucose within the body. It's involved in various common metabolic diseases, including type 2 diabetes, obesity, cardiovascular disease, hyperlipidaemia, and so on. Some studies proved that a number of gene polymorphism sites in LXR were linked with metabolic diseases. Studying the pathological mechanism of LXR in metabolic diseases and researching the correlation between gene polymorphism of LXR and metabolic diseases are beneficial to detecting and assessing the risks of metabolic diseases genetically, which can discover and prevent the diseases early so as to improve the quality of life of patients and prolong living time. This review focuses on the metabolism of LXR and the correlation between the gene polymorphism and metabolic diseases of LXR.