| 国产FDG模块半自动合成~(18)F-氟乙基胆碱 |
| |
| 引用本文： | 周明,张晓军,刘健,李云钢,张锦明.国产FDG模块半自动合成~(18)F-氟乙基胆碱[J].同位素,2016,29(1):19-24. |
| |
| 作者姓名： | 周明 张晓军 刘健 李云钢 张锦明 |
| |
| 作者单位： | 1. 中南大学湘雅医院PET中心,湖南长沙,410008;2. 中国人民解放军总医院核医学科,北京,100853 |
| |
| 摘 要： | 18F-氟乙基胆碱(18F-FECH)是18F-FDG的重要补充,在脑瘤转移和前列腺癌及转移的诊断方面有重要的应用价值。利用国产单次PET-FDG-TI-I CPCU型FDG合成模块,未改变硬件,通过更改试剂与耗材,半自动合成18F-FECH,并在产品收集瓶前增加C18纯化柱,减少K2.2.2杂质的含量。合成时间约30min,放化产率42.0%(未时间校正,n=5),放置6h后放化纯度99.0%,体外稳定性良好;合成时间和产率与国内外模块结果相近。结果表明,在国产单次PET-FDG-TI-I CPCU型FDG模块上可半自动合成18F-FECH,合成效率及放化纯度较高。
|
| 关 键 词： | 18F-氟乙基胆碱(18F-FECH) PET 显像剂 |
The Semi-automatic Synthesis of 18F-fluoroethyl-choline by Domestic FDG Synthesizer |
| |
| ZHOU Ming,ZHANG Xiao-jun,LIU Jian,LI Yun-gang,ZHANG Jin-ming.The Semi-automatic Synthesis of 18F-fluoroethyl-choline by Domestic FDG Synthesizer[J].Isotopes,2016,29(1):19-24. |
| |
| Authors: | ZHOU Ming ZHANG Xiao-jun LIU Jian LI Yun-gang ZHANG Jin-ming |
| |
| Affiliation: | 1.PET Center, Department of Nuclear Medicine, XiangYa Hospital, Central South University , Changsha 410008, China;2.Department of Nuclear Medicine, the PLA General Hospital, Beijing 100853, China |
| |
| Abstract: | As an important complementary imaging agent for 18F-FDG,18F-fluoroethyl-choline (18F-FECH) has been demonstrated to be promising in brain and prostate cancer imaging. By using domestic PET-FDG-TI-I CPCU synthesizer,18F-FECH was synthesized by different reagents and consumable supplies. The C18 column was added before the product collection bottle to remove K2.2.2. The 18F-FECH was synthesized by PET-FDG-IT-I synthesizer efficiently about 30 minutes by radiochemical yield of 42.0% (no decay corrected, n=5), and the radiochemical purity was still more than 99.0% after 6 hours. The results showed the domestic PET-FDG-IT-I synthesizer could semi-automatically synthesize injectable 18F-FECH in high efficiency and radiochemical purity. |
| |
| Keywords: | 18 F-fluoroethyl-choline (18F-FECH) PET imaging agent |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《同位素》浏览原始摘要信息 |
|
点击此处可从《同位素》下载全文 |
|
