Fabrication and degradation of poly(l-lactic acid) scaffolds with wool keratin |
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| Authors: | Jiashen Li Yi Li Lin Li Arthur FT Mak Frank Ko Ling Qin |
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| Affiliation: | aInstitute of Textiles and Clothing, The Hong Kong Polytechnic University, Hong Kong, China;bDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China;cDepartment of Materials Engineering, AMPEL, The University of British Columbia, Vancouver, Canada;dDepartment of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China |
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| Abstract: | As a natural protein, wool keratin was used to improve the cell affinity of poly(l-lactic acid) (PLLA). Small keratin particles were prepared from keratin solution by the spray-drying process. Keratin particles were blended with PLLA/1,4-dioxane solution and paraffin micro-spheres which were used as progens. After the mixture was molded and dried, the paraffin micro-spheres were removed by cyclohexane. PLLA/keratin scaffolds with controlled pore size and well interconnectivity were fabricated. Keratin releasing rate was detected by Fourier transform infrared (FTIR) after the scaffold was immersed into PBS up to 4 weeks. The surface chemical structure was examined by X-ray photoelectron spectroscope (XPS). The results suggested that the keratin could be held into the scaffold which was expected to improve the interactions between osteoblasts and the polymeric scaffolds. |
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| Keywords: | A Polymer– matrix composites (PMCs) D Infrared (IR) spectroscopy D Photoelectron spectroscopy (XPS) Wool keratin |
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