两种分子量壳聚糖抗疲劳作用的研究

目的:以小鼠为实验对象,研究两种分子量和剂量的壳聚糖对小鼠的抗疲劳作用的影响。方法:用相对分子质量为2.4×103和7.6×104的壳聚糖给小鼠灌胃18d,测定游泳时间、血糖和乳酸含量;至24d测定肝糖原和肌糖原含量。结果:两种分子量和不同剂量的壳聚糖均能延长小鼠游泳时间、加速游泳后血糖恢复和乳酸清除并提高游泳前后肝糖原和肌糖原的含量;与同剂量的高分子量壳聚糖相比,低分子量壳聚糖显示了更优的抗疲劳作用。结论:壳聚糖具有抗疲劳作用且与其分子量有关。

Studies on Anti-fatigue Effects of Different Molecular Weights Chitosan

Objective To study the effects of different dosages and different molecular weights chitosan on mice swimming time and changes of blood glucose, lactic acid and glycogen content in mice. Methods: The test groups were given chitosan by oral administration. 18 days later, the swimming time, blood glucose and lactic acid were determined. 24 days later, liver and muscle glycogen were assayed. Results: In contrast with the control group, chitosan could prolong the swimming time, speed up the recover of blood glucose, scavenge lactic acid, and increase the liver and muscle glycogen content. At the same time, low molecular weight chitosan displayed better effect than high molecular weight chitsoan of the same dosage. Conclusion: Chitosan had anti-fatigue effects on mice and low molecular weight chitosan exhibited better effect.