| 高含量全反式番茄红素的全合成方法研究 |
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| 引用本文： | 俞伊莎,;李珊珊,;晏弥卉,;陈浙蓉,;陈建辉. 高含量全反式番茄红素的全合成方法研究[J]. 浙江化工, 2014, 0(8): 17-20 |
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| 作者姓名： | 俞伊莎, 李珊珊, 晏弥卉, 陈浙蓉, 陈建辉 |
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| 作者单位： | [1]绍兴文理学院化学化工学院,浙江绍兴312000; [2]浙江医药股份有限公司新昌制药厂,浙江绍兴312500 |
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| 基金项目： | 浙江省大学生科技创新活动计划（新苗人才计划）项目（2013R426002） |
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| 摘 要： | 设计了番茄红素的全合成绿色新工艺,采用弱碱性交换树脂催化醛酮缩合,用格氏试剂诱导制备六碳醇,与亚磷酸三乙酯发生Wittig-Horner反应制备六碳膦酸酯,再以甲基庚烯酮为起始原料,经Darzen反应与六碳膦酸酯缩合,经过格氏,催化氢化,脱水,手性拆分制备全反式十五碳磷酸酯,与十碳双醛对接,得高含量全反式番茄红素。
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| 关 键 词： | 番茄红素 全合成 绿色新工艺 高含量 全反式 |
Study on the Total Synthesis of High Content All-trans Lycopene |
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| YU Yi-sha;LI Shan-shan;YAN Mi-hui;CHEN Zhe-rong;CHEN Jian-hui. Study on the Total Synthesis of High Content All-trans Lycopene[J]. Zhejiang Chemical Industry, 2014, 0(8): 17-20 |
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| Authors: | YU Yi-sha LI Shan-shan YAN Mi-hui CHEN Zhe-rong CHEN Jian-hui |
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| Affiliation: | YU Yi-sha, LI Shan-shan, YAN Mi-hui, CHEN Zhe-rong, CHEN Jian-hui(1.College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, Zhejiang 312000, China; 2. Zhejiang Medicine Co., Ltd., Xinchang Pharmaceutical Factory, Shaoxing, Zhejiang 312500, China) |
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| Abstract: | A total synthesis of lycopene green production process was developed. The synthetic steps were as follows： the condensation between formaldehyde and acetone was catalyzed by weak-base exchange resin, and then the hexacarbinal was prepared by introducing Grignard reagents. The 3-methyl-2-penten-4-yn-1-phosphonate was prepared via the Wittig-Horner reaction between phosphorous acid triethyl ester and hexacarbinal. The all-trans 3,7,11-trymethyldodeca-2,4,6,10- tetraenylphosphonate was produced from methyl heptenone and 3-methyl-2-penten-4-yn-1-phosphonate via the Darzen reaction, Grignard reaction, catalytic hydrogenation, dehydration and enantioseparation. Finally, the target product high levels and all-trans lycopene was obtained by the reaction between all-trans 3,7,11-trymethyldodeca-2,4,6,10-te-traenylphosphonate and 2,7-dimethyl-2,4,6-octatriene-1,8-dial. |
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| Keywords: | lycopene total synthesis green process high content all-trans |
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