| 二脱水山梨醇聚氧乙烯醚油酸酯纯品的合成 |
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| 引用本文： | 贾卫茹,吴云飞,赵鑫,张勇.二脱水山梨醇聚氧乙烯醚油酸酯纯品的合成[J].辽宁化工,2014(6):674-675. |
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| 作者姓名： | 贾卫茹 吴云飞 赵鑫 张勇 |
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| 作者单位： | 辽宁省药物研究院,辽宁沈阳110015 |
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| 基金项目： | 药用辅料（聚山梨酯-80）安全性研究,项目号：2012002004. |
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| 摘 要： | 山梨醇经催化脱水,高真空减压蒸馏得到二脱水山梨醇,与环氧乙烷反应得到二脱水山梨醇聚氧乙烯醚,最后与高纯度油酸缩合得到高纯度组分二脱水山梨醇聚氧乙烯醚油酸酯,是聚山梨酯80的重要组成成分。
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| 关 键 词： | 聚山梨酯 催化 药用辅料 |
Synthesis of Pure Sorbitan Polyoxyethylene Oleate |
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| JIA Wei-ru,WU Yun-fei,ZHAO Xin,ZHANG Yong.Synthesis of Pure Sorbitan Polyoxyethylene Oleate[J].Liaoning Chemical Industry,2014(6):674-675. |
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| Authors: | JIA Wei-ru WU Yun-fei ZHAO Xin ZHANG Yong |
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| Affiliation: | (Liaoning Institute of Pharmaceutical Research, Liaoning Shenyang 110015, China) |
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| Abstract: | Sorbitan was prepared from sorbitol by catalytic dehydration and high vacuum vacuum distillation, the sorbitan reacted with ethylene oxide to get sorbitan polyoxyethylene ether, at last condensation reaction of sorbitan polyoxyethylene ether and high purity oleic acid was carried out to obtain pure sorbitan polyoxyethylene oleate, which is an important component ofpolysorbate 80. |
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| Keywords: | polysorbate 80 catalysis medicinal materials |
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