Knigth's Move in the Periodic Table, From Copper to Platinum, Novel Antitumor Mixed Chelate Copper Compounds, Casiopeinas, Evaluated by an in Vitro Human and Murine Cancer Cell Line Panel |
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Authors: | Gracia-Mora I Ruiz-Ramírez L Gómez-Ruiz C Tinoco-Méndez M Márquez-Quiñones A Lira L R Marín-Hernández A Macías-Rosales L Bravo-Gómez M E |
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Affiliation: | Inorganic Chemistry Department Faculty of Chemistry, UNAM Mexico City Z.P. 04510 Mexico. |
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Abstract: | We synthesized a novel anticancer agents based on mixed chelate copper (II) complexes, named
Casiopeínas® has of general formula Cu(N-N)(N-O)H2O]NO3 (where, N-N = diimines as 1,10- phenanthroline, 2,2-bipyridine, or substituted and N-O=aminoeidate or Cu(N-N)(O-O)H2O]NO3 (where NN= diimines as 10-phenanthroline, 2,2-bipyridine or substituted Casiopeínas I, II, IV, V, VI, VII VIII and
O-O=acetylacetonate, salicylaldehidate Casiopínas III). We evaluated the in vitro antitumor activity using
a human cancer cell panel and some nurine cancer cells. Eleven Casiopeinas are evaluated in order to
acquire some structure-activity correlations and some monodentated Casiopeinäs analogues; cisplatinum
was used as control drug. The 50% growth inhibition observed is, in all cases reach with concentrations of
Casiopeina''s 10 or 100 times lower than cisplatinum. In a previous work we reported the induction of
apoptosis by Casiopeina II. The results indicate that Casiopeinass are a promising new anticancer drug
candidates to be developed further toward clinical trials. |
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