阪崎克罗诺肠杆菌致病性机理研究进展

阪崎克罗诺肠杆菌是一种革兰氏阴性无芽孢肠道杆菌，可导致新生儿和免疫功能不全的婴幼儿严重脑膜炎、菌血症和坏死性结肠炎，是一种非常重要的食源性条件致病菌。目前，国内外对阪崎克罗诺肠杆菌的致病性及其致病机理的研究报道非常有限。本文通过阪崎克罗诺肠杆菌外膜蛋白A、脂多糖、生物膜、宿主细胞骨架、铁获得机制、海藻糖的存在、超广谱β-内酰胺酶的产生和细胞间相互作用等方面对阪崎克罗诺肠杆菌的致病性机理进行综述。

Progress in Understanding the Pathogenic Mechanism of Cronobacter sakazakii

Cronobacter sakazakii is a gram-negative, sporeless enteric bacillus, and is one of the very important
opportunistic foodborne pathogens associated with meningitis, septicemia, and necrotizing enterocolitis in neonates
and immunocompromised infants. However, information regarding the pathogenicity and pathogenic mechanism of
Cronobacter sakazakii is still limited and not well documented. In this paper, we reviewed the recent progress in the study
of the pathogenic mechanism of Cronobacter sakazakii with reference to outer membrane protein A, lipopolysaccharides,
biofilm, the host cell cytoskeleton, iron acquisition mechanism, the presence of trehalose, the presence of extended-spectrum
β-lactamases, and intercellular interaction.