| 桑葚多糖调节血糖代谢及体外抗氧化效果研究 |
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| 引用本文： | 王强,王睿,王存,龙洁.桑葚多糖调节血糖代谢及体外抗氧化效果研究[J].食品科学,2014,35(11):260-264. |
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| 作者姓名： | 王强 王睿 王存 龙洁 |
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| 作者单位： | 1.重庆第二师范学院生物与化学工程系，重庆 400067；2.重庆第二师范学院教务处，重庆 400067 |
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| 基金项目： | 重庆高校创新团队建设计划资助项目(KJTD201325) |
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| 摘 要： | 研究桑葚多糖（mulberry polysaccharides，MBPs）对糖尿病大鼠的降糖效果及体内外抗氧化活性。在体外化学条件下，测定MBPs清除·OH和O2－·能力；采用链脲佐菌素诱导建立糖尿病大鼠模型，糖尿病大鼠分别灌胃150、300、450 mg/（kg·d）剂量的MBPs。结果表明：MBPs清除·OH和O2－·的EC50分别为0.17、0.54 mg/mL；MBPs能显著改善糖尿病大鼠血糖水平、血脂指标（甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇）、脂质过氧化水平（丙二醛）和血清抗氧化状态（谷胱甘肽过氧化物酶、超氧化物歧化酶及总抗氧化能力）；MBPs具有降血糖作用。
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| 关 键 词： | 桑葚多糖 糖尿病 血糖代谢 抗氧化 |
Effects of Mulberry Polysaccharides on Glucose Metabolism and Their Antioxidant Activities in vitro |
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| WANG Qiang,WANG Rui,WANG Cun,LONG Jie.Effects of Mulberry Polysaccharides on Glucose Metabolism and Their Antioxidant Activities in vitro[J].Food Science,2014,35(11):260-264. |
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| Authors: | WANG Qiang WANG Rui WANG Cun LONG Jie |
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| Affiliation: | 1.Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China;
2. Academic Administration of Chongqing University of Education, Chongqing 400067, China |
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| Abstract: | The purpose of this study was to investigate the hypoglycemic activity of polysaccharides isolated from mulberry
(MBPs) on streptozotocin-induced diabetes in rats and their antioxidant activity in vitro. Their scavenging activities for
hydroxyl and superoxide anion radicals in vitro were determined. The results showed that the EC50 values of MBPs for
hydroxyl and superoxide anion radical scavenging were 0.17 and 0.54 mg/mL, respectively. MBPs had a significant
improvement on blood glucose levels, serum lipid parameters (triglyceride, total cholesterol, low density lipoproteincholesterol
(LDL-C), high density lipoprotein-cholesterol (HDL-C)), lipid peroxidation (malondiadehyde content) and serum
antioxidant status (glutathione-peroxidase (GSH-Px), superoxide dismutase (SOD), total antioxidant capacity (T-AOC)) in
diabetic rats. This study may provide experimental evidence for the development of antihyperglycemic agent from mulberry
polysaccharides. |
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| Keywords: | mulberry polysaccharides diabetes glucose metabolism antioxidant activity |
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