脱氢醋酸钠对断奶仔猪抗氧化能力的影响

研究食品添加剂脱氢醋酸钠对动物抗氧化能力的影响。以仔猪作为实验动物模型，选用10 日龄哺乳仔猪（杜×长×大）192 头，随机分成4 组（每组4 个重复，每重复12 头），饲喂不含脱氢醋酸钠的基础日粮（对照组）、基础日粮中分别添加脱氢醋酸钠0.02%（实验组Ⅰ）、0.1%（实验组Ⅱ）和0.2%（实验组Ⅲ）的日粮，实验期42 d。结果表明：与对照组相比，1）仔猪51 d体质量，Ⅲ组显著降低13.26%（P＜0.05），Ⅰ、Ⅱ组无显著差异（P＞0.05）；2）Ⅲ组仔猪血清超氧化物歧化酶（superoxide dismutase，SOD）活力极显著降低（P＜0.01），总抗氧化能力（total antioxidant capacity，T-AOC）显著降低（P＜0.05），而Ⅰ、Ⅱ组仔猪血清抗氧化指标均无显著差异（P＞0.05）；3）仔猪肝脏丙二醛（malondialdehyde，MDA）含量，除Ⅲ组外，Ⅰ（P＜0.01）、Ⅱ（P＜0.05）组均有明显升高。因此，日粮中添加0.2%脱氢醋酸钠，明显降低仔猪的抗氧化能力，食品中使用高剂量脱氢醋酸钠存在一定的健康风险。

Effects of Sodium Dehydroacetate on Antioxidant Capacity in Weaned Piglets

The effects of sodium dehydroacetate on antioxidant capacity in weaned piglets were investigated. A total of 192
crossbreds (Duroc × Landrace × Yorkshire) piglets at 10 days of age were randomly divided into 4 groups with 4 replicates
consisting of 12 animals each. They were weaned and fed with basal diet (control group), basal diet supplemented with
0.02% (group Ⅰ), 0.1% (group Ⅱ) and 0.2% (group Ⅲ) sodium dehydroacetate, respectively. The experiment lasted for 42
days. The results showed that when comparing with the control group: 1) the weight of the 51-day-old piglets in group Ⅲ
was significantly decreased by 13.26% (P ＜ 0.05), while groups Ⅰ and Ⅱ had no significant difference (P ＞ 0.05); 2)
the serum total superoxide dismutate (T-SOD) in group Ⅲ was decreased highly significantly (P ＜ 0.01), in addition to a
significant reduction in serum total antioxidant capacity (T-AOC) (P ＞ 0.05). But the serum antioxidant indices in groups Ⅰ
and Ⅱ had no significant difference; and 3) the liver malondialdehyde (MDA) contents in groups I (P ＜ 0.01) and Ⅱ
(P ＜ 0.05) but not in group Ⅲ were increased significantly. These results indicate that the diet containing 0.2% sodium
dehydroacetate could significantly decrease the TAC in piglets. Thus some potential health risks may be caused by using
high levels of sodium dehydroacetate in food.