响应面法优化虾青素微胶囊制备工艺

微胶囊化包埋可减缓虾青素的氧化速度。以羟丙基-β-环糊精（hydroxypropyl-β-cyclodextrin，HP-β-CD）、麦芽糊精为壁材，采用喷雾干燥法制备虾青素微胶囊。在单因素试验的基础上，以虾青素微胶囊包埋率为响应值，以壁材比例、壁材质量浓度、蔗糖酯添加质量分数3 个因素为响应因子，利用响应面法建立了二次回归实际方程模型，获得了制备虾青素微胶囊的最佳工艺条件为：m（HP-β-CD）∶m（麦芽糊精）= 2.9∶1，壁材质量浓度0.21 g/mL，蔗糖酯添加质量分数2%，虾青素添加质量分数4%，喷雾进风温度170 ℃。按此最佳工艺条件制备的虾青素微胶囊包埋率达95.31%。

Optimization of Preparation Process for Microencapsulated Astaxanthin with Response Surface Methodology

Microencapsulation is an effective method to protect the stability of astaxanthin from environmental factors.
Astaxanthin was microencapsulated by spray drying method using hydroxypropyl-β-cyclodextrin (HP-β-CD) and
maltodextrin as wall materials. Based on single factor experiments, the microencapsulation conditions were optimized using
response surface methodology. A mathematical regression model was established for predicting the microencapsulation
efficiency of astaxanthin at different levels of proportion of HP-β-CD to maltodextrin, wall material concentration and
sucrose ester concentration. The optimal microencapsulation conditions were determined as follows: a ratio of HP-β-CD to
maltodextrin of 2.9:1, 0.21 g/mL wall materials, 2% sucrose ester, 4% astaxanthin, and a spray air inlet temperature of 170 ℃.
Under the optimized conditions, the microencapsulation efficiency was 95.31%.