| 环孢素对肾移植术后患者血脂影响的浓度依赖性 |
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| 引用本文： | 徐峰,吴朝晖,张忠义,邹恒琴. 环孢素对肾移植术后患者血脂影响的浓度依赖性[J]. 金属学报, 1997, 2(3): 165-168 |
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| 作者姓名： | 徐峰 吴朝晖 张忠义 邹恒琴 |
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| 作者单位： | 第一军医大学珠江医院, 广州 510282 |
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| 摘 要： | 目的 研究环孢素对血脂影响的浓度依赖性。方法 对16 例肾移植术后患者测定术前和术后血脂及环孢素血药浓度。结果 在环孢素血药浓度与术后术前血浆胆固醇及甘油三酯差值之间无统计学相关性。但术后血浆胆固醇的增加在高浓度患者中具有统计学显著性(P>0.05)。结论 环孢素对肾移植术后患者血脂的影响呈浓度依赖性。
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| 关 键 词： | 环孢素 药物不良 反应 血脂 肾脏移植 |
| 收稿时间： | 1997-06-25 |
| 修稿时间： | 1997-07-25 |
Concentration-dependent effect of cyclosporine on plasma lipid in renal transplant recipients |
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| Xu Feng,Wu Zhaohui,Zhang Zhongyi,Zou Hengqing. Concentration-dependent effect of cyclosporine on plasma lipid in renal transplant recipients[J]. Acta Metallurgica Sinica, 1997, 2(3): 165-168 |
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| Authors: | Xu Feng Wu Zhaohui Zhang Zhongyi Zou Hengqing |
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| Affiliation: | Department of Clinical Pharmacology, Zhujiang Hospital, First Military Medical University, GuangZhou 510282 |
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| Abstract: | Aim To investigate the concent ration-dependent effect of cyclosporine on plasma lipid.Methods Pre-and post-transplant plasma lipid and cyclosporine whole blood concent ration were determined in 16 renal transplanted recipients with stable graft function.Results No statistically significant correlations were found between cyclosporine whole blood concent ration and plasma cholesterol and triglyceride increase-difference.However, post-t ranplant plasma cholesterol level was increased in renal transplanted recipients with high blood concent ration of cyclosporine(P<0.05).Conclusion The effect of cyclo sporine on plasma lipid in renal transplanted recipient is concent ration-dependent. |
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| Keywords: | cyclo sporine adverse drug reaction plasma lipid renal transplantation |
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