| 茶多酚对缺血心肌组织PIP2和IP3水平的影响 |
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| 引用本文： | 柯永胜,赵振东. 茶多酚对缺血心肌组织PIP2和IP3水平的影响[J]. 金属学报, 1996, 1(1): 21-22 |
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| 作者姓名： | 柯永胜 赵振东 |
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| 作者单位： | 皖南医学院弋矶山医院,芜湖 241001 |
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| 摘 要： | 目的 观察荼多酚对急性缺血心肌磷酯肌醇代谢的影响。方法 结扎大鼠左冠状动脉前降支造成急性心肌缺血模型。结果 急性心肌缺血10min,心肌磷酯肌醇代谢功能增强,缺血组心肌PIP2、IP3水平明显高于非缺血对照组(P<0.01);茶多酚能显著抑制急性心肌缺血所致心肌组织PIP2和IP3水平的升高。结论 茶多酚心肌保护作用与抑制缺血心肌组织磷酯肌醇代谢有关。
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| 关 键 词： | 心肌缺血 磷酯酰肌醇-4 5-二磷酸 肌醇-1 4 5-三磷酸 茶多酚 |
| 收稿时间： | 1996-03-12 |
| 修稿时间： | 1996-05-20 |
Effects of tea ployphenols on levels of PIP2,IP3 of acute schemic myocardium in rat |
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| Ke Yongsheng,Zhao Zhengdong. Effects of tea ployphenols on levels of PIP2,IP3 of acute schemic myocardium in rat[J]. Acta Metallurgica Sinica, 1996, 1(1): 21-22 |
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| Authors: | Ke Yongsheng Zhao Zhengdong |
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| Affiliation: | Department of Medicine, Yijishan Hospital, Wannan Medical College, Wuhu 241001 |
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| Abstract: | Aim The effects of tea polyphenols (TP) on phosphoinositides metablism in rats with acute ischemic myocardium were studied. Methods The model of acut myocardial ischemia in rats was prepared by ligating anterior decending branch of left coronary artery. Results The functio1l of the phosphoinositide signal system was enhanced 10 min after acute myocardial is-chemia. Both of the levels of phosphotidylinositol-4,5-biphosphate(PIP2) and inositol -1,4,5-triphosphate (IP3)were higher than those in the non - ischemic control group(P<0.01).The rise of the levels of PIP2 and IP3 caused by myocardial ischemia were remarkedly in-hibited by the TP and a dose - effect relalionship was observed (P<0.01). Conclusion The results showed that the protection of TP was relation to its inhibiting the function of phosphoinositides metablism in acute ischemic myocardium. |
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| Keywords: | Myocardial ischemia Phosphotidylinositol-4 5-biphosphate Inositol-1 4 5-triphosphate Tea polyphenols |
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