月见草胶囊治疗十二指肠溃疡近期疗效及治疗前后胃粘膜血流量、跨粘膜变化

目的 观察富含亚油酸的月见草胶囊(以下简称月见草)治疗十二指肠溃疡近期效果,并初步探讨其作用机制。方法 月见草(1.5g,3/d)与雷尼替 丁(0. 15 g,2/d)分别治疗十二指肠溃疡31例、32例,疗程4周,观察治疗效果,并测定治疗前后胃粘膜血流量、跨粘膜电位。结果 月见草与雷尼替丁治疗十二指肠溃疡4周治愈率分别为87.1%、87.5%,两者之间无明显差异(P>0.05),同时发现月见草治疗前后胃粘膜血流量、粘膜电位显著增加(P<0.05)。结论 月见草对治疗溃疡病有良效,其作用机制可能与其大幅度增加胃粘膜血流量及跨膜电位有关。

The effectiveness of Y uejiancao in the treatment of duodenal ulcer and the changes of GMBF,PD after treatment

Aim This study aims mainly to explore the effectiveness and mechanism of Y uejiancao, a preparation abounding in linoleic acid (75%+) in the treatment of duodenal ulcer. Methods Yuejiancao (1.5g tid) was used respectively in 31 patients with dodenal ulcer and raniti-dine(0.15g,bid) in 32 matched control patients with the same disease for four weeks. The effectiveness of treament was obseverd by the examination of gastroendoscopy, and the values. of GMBF and PD were determined before and after treatment. Results A 87. 10% response. rate was acquired in Y uejiancao treated patients and a 87. 50% response rate in ranitidine group. There was no statistical difference between two groups. GMBF and PD increased significantly after treatment with Yuejiancao (P<0.05). Conclusion These findings sug-gest that Yuejiancao is an effective agent for treating peptic ulcerous disease. The effectire meckanism of Yuejiancao is mediated by significantly increasing GMBF and PD(P<0. 05).