通痹汤与氨甲喋呤联合治疗类风湿性关节炎疗效观察

目的 观察通痹汤与氨甲喋呤联合治疗类风湿关节炎疗效。方法 治疗组采用中药通痹汤与氨甲喋呤联合治疗类风湿性关节炎(RA)79例,以凤湿液与氨甲喋呤联合治疗的40例RA作对照。其中治疗组18例,对照组9例。结果与结论 两组疗效均比文献所报告的单用氨甲喋呤疗效为佳。而通痹汤更具较强的抗炎镇痛及免疫调节作用,可使关节肿痛症状迅速消失,关节功能明显改善,晨僵时间消失或缩短,并随着关节炎症的减轻,使血液中IgG,IgM,IgA恢复正常,血沉下降曲线平稳,类风湿因子(RF)阴转率达67.57%。用药后撤停激素快,无反跳现象,副作用少。骨质修复作用明显,具有改善病情作用。其疗效明显优于对照组。

Curative effect of tongpitang combined with methotrexate on rheumatoid arthritis

Aim The efficacy of Tongpitang (a recipe consisting of 19 Chinese medicinal herbs)decoction in combination with methotrexate (MTX)against rheumatoid arthritis (RA)was to be observed.Methods Tongpitang (once daily)and MTX (7.5mg once weekly)were prescribed to 79 patients with RA for 3 months as a course.Serving as control, other 40 cases of RA were prescribed Fengshiye (a traditional Chinese medicinal preparation)combined with MTX.Eighteen cases from the Tongpitang group and nine cases from the control group were supplementally injected with Fengsiling.Results In comparison with the control, Tongpi-tang combined with MTX gave significant efficacy in relieving joint swelling and pain, shortening the morning stiffness, restoring IgG, IgM and IgA and dropping sedimentation.The negative conversion rate of rheumatoid factors reached 67.75%.There was no side- effect during hormone administration or rebound phenomeonafter stoping it.Conclusions Compared with single MTX of Fengshiye plus MTX, Tongpitang in combination with MTX gives the best curative effect in the treatment of rheumatoid arthritis.