壮骨肾宝对实验性小鼠高脂血症的影响

目的 观察由黄芪 、白术 、淫羊藿组成的复方制剂(壮骨肾宝)对实验性小鼠高脂血症的影响。 方法 用蛋黄乳液快速致小鼠单纯性高胆固醇血症和喂养高脂饲料致高脂血症模型, 观察预 防性给予不同剂量的壮骨肾宝后对血清总胆固醇 (TC)、甘油三酯(TG)和高密度脂蛋白胆固 醇(HDL-ch)的影响。结果 壮骨肾宝中 、高剂量能使血清 TC 降低(P <0.05),HDL-ch 升 高(P <0.01), 但对 TG 的影响不大。结论 壮骨肾宝有一定降血脂作用, 并与剂量有关。

Effects of Zhuanggushenbao on hyperlipoidemia in mice

Aim The action of lowing serum lipid of Zhuanggushenbao, which was prepared from Epimedium, Astragalus Land Atractylodes, was observed.Methods Mouse hypercholes-terolemia model by injecting yolk and mouse hyperlipoidemia model by fedding high lipid foods were set up.The effects of Zhuanggushenbao in its low, medium and high dose on serum total cholesterol (TC), triglyceride (TG)and high density lipoprotein-chlesterol (HDL-ch)were studied. Results Medium and high dose Zhuanggushenbao could reduce serum TC (P <0.05), and increase HDL-ch obviously (P <0.01).But it could not affect serum TG nearly. Conclusion Zhuanggushenbao has a dose-effect relationship on lowing blood lipid.