肾病综合征患者可溶性白介素2受体变化及意义

目的 研究肾病综合征患者可溶性白介素2受体（SIL-2R)变化及临床意义。方法 36例肾病 综合征患者及20例徤康志愿者血、尿标本, 用EL IS A法检測其SI L-2R浓度。结果 肾病综合 征发作期（252 ± 109u/ml, 167 ± 80u/ml, n = 22)血清及尿液SIL-2R浓度明显高于肾病综合征 缓解期（120±26u/ml, 101±46u/ml, w = 14)及徤康对照者（113± 110u/ml, 84± 18u/ml, n = 20, P<0. 01);肾病综合征缓解期和健康对照者无明显差别（P> 0. 05)。血清SIL-2R浓度和 血肌酐浓度呈正相关（r = 0. 44, P< 0. 01);尿液SIL-2R、浓度和來蛋白是呈正相关（r = 0. 48, P< 0. 01)。结论 SIL-2R浓度升高可作为肾病综合征活动及（或）肾功能恶化的指标。

Change of soluble Interleukin-2 receptor and its significance in nephrotic syndrome patients

Aim To investigate the clinical significance of SIL-2R concentrations. Methods Serum and urine soluble interleukin-2 receptors (SIL-2R) were determined with the ELISA method in 36 cases of nephrotic syndrome patients and 20 cases of health volunteers. Results The serum and urine SIL-2R concentrations in the nephrotic stage group (252± 109u/ml, 167 ± 80u/ ml, n = 22) exceeded those in non-nephrotic stage group (120 ± 26u/ ml, 101 ± 46u/ml, n = 14, P<0. 01) and those in healthy controls (113 ± 110u/ml, 84 ± 19u/ml, n = 20, P< 0. 01). There were not any differences in serum and urine SIL-2R concentrations between non-nephrotic stage group and healthy controls (P> 0. 05). Serum SIL-2R con-centrations were correlated with serum creatinine (r = 0. 44, P<0. 01), and urine SIL-2R concentrations were correlated with urine protein excretion (r = 0. 48, P< 0. 01). Conclusion Higher concentration of SIL-2R can serve as an indicator of nephrotic syndrome and (or) renal function exacerbation.