氨茶喊对人体心电图和定量脑电图的影响及其与唾液氨茶碱含量的关系

目的 评价氣茶城对人体心电-图和定量脸电图的影响及其与嗟液氣茶城含量的关系。方法 米 用双盲安慰剂对照, 研究了良茶碱对10例徤康人心电图和定量脑电图的影响。结果 顿服氦茶碱 0. 4g, 2h 后心电图R波振幅从9. 9±2. 8m增高到12. 0±3. 6m(P<0. 05);定量脑电图f_pt导 联a₂波功率值从1. 05±0. 83上升到2. 08±2. 22(P<0. 05), f₃和f₄导联β₁波功率值从 1. 75± 1. 35升高到3. 11±3. 51(P< 0. 05);唾液氩茶碱含量为7. 6±0. 9 μg/ml。心电图R波及 脑电图a₂ 波的变化与哇液氩茶城含量呈正相关（r值分别为0. 8264和0. 7933)。10例口服安慰 剂健康受试者, 其心电困和脑电图改变均无统计学显著性。结论 治疗浓度氩茶碱能引起人体 心电和脑电的改变, 效应强度与游离药物浓度有关。

Effects of theophylline on ECG and QEEG mapping in man and correlation between the effects and the drug level in saliva

Aim This study was designed to evaluate the effect of theophylline on ECG and QEEG map-pong in healthy volunteers and correlation between the effects and the drug level in saliva. Methods The effects of theophylline on ECG and QEEG mapping in healthy volunteers were studied in a double-blind and placebo controlling. Results Two hours after taking theophylline 0. 4g, the amplitude of R wave in ECG rose from 9. 9 ± 2. 8mV to 12. 0 ± 3. 6mV(P < 0. 05); a₂ wave power in f_p lead and β₁ wave power in f₃ and f₄ leads increased from 1. 05 ± 0. 83 to 2. 08 ± 2. 22(P< 0. 05) and from 1. 75± 1. 35 to 3. 11±3. 51(P<0. 05) respectively; and the theophylline level in saliva was 7. 6 ± 0. 9 pg/ml, existing the correlation between the changes of R wave amplitude and ai wave power and the drug level in saliva (r = 0. 7933 and 0. 8264). Conclusion The experimental results indicated that the theophylline at treatment concentration could cause the changes of ECG and QEEG mapping in healthy volunteers, which was correlation with the level of the freedrug.