| 褪黑素对小鼠抗氧化作用的影响 |
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| 引用本文： | 代国杰,朱建津,高琳琳,单立娟.褪黑素对小鼠抗氧化作用的影响[J].食品工业科技,2010(3). |
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| 作者姓名： | 代国杰 朱建津 高琳琳 单立娟 |
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| 作者单位： | 江南大学食品学院食品营养与功能因子研究中心,江苏,无锡,214122 |
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| 摘 要： | 目的:研究小鼠在受到脂多糖(LPS)刺激时,褪黑素的抗氧化作用,并探讨其可能机制。方法:用脂多糖建立氧化应激模型,检测血清、小肠、肝脏和脾组织中的ROS含量,肝脏、脾组织中的谷胱甘肽过氧化物酶(GSH-PX)、超氧化物歧化酶(SOD)、丙二醛(MDA)的变化。结果:在LPS刺激后的4h和16h,褪黑素均能降低血清、小肠、肝脏、脾组织中的ROS含量,提升肝脏和脾组织中的GSH-PX、SOD活性,降低MDA含量。结论:褪黑素有助于增强氧化应激小鼠的抗氧化能力,降低组织中NO含量与NO合成酶活性,增加了SOD、GSH-PX等抗氧化酶的活性,保护机体免受氧化损伤。
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| 关 键 词： | 褪黑素 LPS ROS GSH-PX SOD MDA |
Effect of melatonin on the antioxidation of mice |
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| DAI Guo-jie,ZHU Jian-jin,GAO Lin-lin,SHAN Li-juan.Effect of melatonin on the antioxidation of mice[J].Science and Technology of Food Industry,2010(3). |
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| Authors: | DAI Guo-jie ZHU Jian-jin GAO Lin-lin SHAN Li-juan |
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| Affiliation: | DAI Guo-jie,ZHU Jian-jin,GAO Lin-lin,SHAN Li-juan (Institute of Food Nutrition , Functional Factor School of Food Science , Technology,Jiangnan University,Wuxi 214122,China) |
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| Abstract: | Objective:To study the effects of melatonin on antioxidation and its mechanism on mice under the stimulation of lipopolysaccharide(LPS).Method:To determine changes on reactive oxygenspecial(ROS),superoxidedismutase(SOD),glutathioneperoxidase(GSH-PX),malondialdehyde(MDA) by melatonin under lipopolysaccharide(LPS) induced oxidative response.Results:serum,small intestine,hepatic and spleen ROS were decreased,Hepatic and spleen,SOD,GSH-PX were increased and MDA were decreased with Melatonin supplement 4h and 16... |
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| Keywords: | melatonin(MT) lipopolysaccharide(LPS) reactiveoxygenspecial(ROS) glutathioneperoxidase(GSH-PX) superoxidedismutase(SOD) malondialdehyde(MDA) |
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