Study of load capacity of Avicel PH-200 and Cellactose, two direct compression excipients, using experimental design |
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Authors: | Estrada Flores L Lopez Arellano R Díaz Esquivel J J |
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Affiliation: | Sanofi Synthélabo S. A. de C. V., Cuautitlán, Mexico. |
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Abstract: | The load capacity of two excipients, a large particle size grade of microcrystalline cellulose (Avicel™ PH-200) and a coprocessed material composed of lactose and pulverized cellulose (Cellactose™) was determined using a model mix with Dipyrone (metamizol sodium) and experiments planned by design of experiments. A multiple-regression model was proposed, and as a result, a new parameter, called specific load capacity SLC was obtained. This constant can be determined for other excipients and drugs; it depends only on the excipient and the drug used. |
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Keywords: | Cellactose Load capacity Metamizol sodium Microcrystalline cellulose |
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