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Solubility of N-chloro succinimide in different pure solvents in the temperature range from 278.15 K to 333.15K
Authors:Jing Zhu  Fei Shen  Yong-Hong Hu  Xin-min Jiang  Dong-yun Li
Affiliation:2. School of Pharmaceutical Sciences, Nanjing University of Technology, Nanjing, 211816, China
1. Jiangsu Engineering Technology Research Center of Polypeptide Pharmaceutical, Nanjing, 210009, China
Abstract:Solubility data were measured for N-chloro succinimide in pure n-butanol, ethyl acetate, acetone, isopropanol, tetrahydrofuran, acetonitrile and acetic anhydride at the temperature range between 278.15 K and 333.15 K under atmospheric pressure by gravimetric method. The solubility of N-chloro succinimide in those selected solvents increased with increasing temperature. The solubility data were correlated with the modified Apelblat equation and the van??t Hoff equation to obtain the model parameters. The experimental results could be useful for optimizing the process of purification of N-chloro succinimide in industry. Isopropanol could be the excellent solvent in the crystallization of N-chloro succinimide.
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