Nanomaterials for X-ray imaging: gold nanoparticle enhancement of X-ray scatter imaging of hepatocellular carcinoma |
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Authors: | Rand Danielle Ortiz Vivian Liu Yanan Derdak Zoltan Wands Jack R Tatíček Milan Rose-Petruck Christoph |
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Affiliation: | Department of Chemistry, Brown University, Providence, Rhode Island 02912, United States. |
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Abstract: | We present the development of a new imaging technique for the early diagnosis of hepatocellular carcinoma that utilizes surface-modified gold nanoparticles in combination with X-ray imaging. Tissues labeled with these electron-dense particles show enhanced X-ray scattering over normal tissues, distinguishing cells containing gold nanoparticles from cells without gold in X-ray scatter images. Our results suggest that this novel approach could enable the in vivo detection of tumors as small as a few millimeters in size. |
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