Relationships between the fatty acid composition of muscle and erythrocyte membrane phospholipid in young children and the effect of type of infant feeding |
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Authors: | Louise A Baur Janice O’Connor David A Pan Ben J Wu Marcus J O’Connor Leonard H Storlien |
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Affiliation: | (1) Department of Paediatrics and Child Health, University of Sydney, 2006, NSW, Australia;(2) Department of Botany and Plant Pathology, Michigan State University, 48824, Michigan;(3) Metabolic Research Centre, Faculty of Health and Behavioural Sciences, University of Wollongong, 2522 Wollongong, NSW, Australia;(4) School of Information Systems, Technology and Management, University of New South Wales, 2052 Sydney, NSW, Australia;(5) Department of Paediatrics and Child Health, The Royal Alexandra Hospital for Children, P.O. Box 3515, 2124 Parramatra, NSW, Australia |
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Abstract: | Muscle membrane fatty acid (FA) composition is linked to insulin action. The aims of this study were to compare the FA composition
of muscle and erythrocyte membrane phospholipid in young children; to investigate the effect of diet on these lipid compositions;
and to investigate differential incorporation of FA into muscle, erythrocyte and adipose tissue membrane phospholipid, and
adipose tissue triglyceride. Skeletal muscle biopsies and fasting blood samples were taken from 61 normally nourished children
(15 males and 16 females), less than 2 yr old (means ±SE, 0.80±0.06 yr), undergoing elective surgery. Adipose tissue samples
were taken from 15 children. There were significant positive correlations between muscle and erythrocyte docosahexaenoic acid
(DHA) (r=0.44, P<0.0001), total n−3 polyunsaturated fatty acids (PUFA) (r=0.39, P=0.002), and the n−6/n−3 PUFA ratio (r=0.39, P=0.002). Adipose tissue triglyceride had lower levels of long-chain PUFA, especially DHA, than muscle and erythrocytes (0.46±0.18%
vs. 2.44±0.26% and 3.17±0.27%). Breast-fed infants had higher levels of DHA than an age-matched group of formulafed infants
in both muscle (3.91±0.21% vs. 1.94±0.18%) and erythrocytes (3.81±0.10% vs. 2.65±0.23%). The results of this study show that
(i) erythrocyte FA composition is a reasonable index of muscle DHA, total n−3 PUFA, and the n−6/n−3 PUFA ratio; (ii) breast
feeding has a potent effect on the FA composition of all these tissues; and (iii) there is a wide range in long-chain PUFA
levels in muscle, erythrocytes, and adipose tissue. |
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