Bone-like forming ability of apatite-wollastonite glass ceramic |
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Authors: | M Magallanes-PerdomoZB Luklinska AH De Aza RG CarrodeguasS De Aza P Pena |
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Affiliation: | a Instituto de Cerámica y Vidrio (ICV-CSIC). C/Kelsen 5, Madrid-28049, Spain b Queen Mary University of London, Materials Dept., London E1 4NS, United Kingdom |
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Abstract: | This research describes the preparation, characterisation and in vitro behavior of a bioactive glass ceramic containing 44.8 wt% apatite, 28.0 wt% wollastonite-2 M and 27.2 wt% of amorphous phase. The biomaterial was obtained by a specific thermal cycle process that caused the devitrification of the Ca3(PO4)2-CaSiO3 binary system's stoichiometric eutectic composition. Overall, the material combines the properties of a resorbable Si-Ca-rich glass, in addition to bioactive properties of wollastonite and apatite phases. The bioactivity of this material was studied by soaking the samples in a simulated body fluid (SFB) for 3, 7, 14 and 21 days at 36.5 °C. During the soaking, the amorphous phase and also wollastonite-2 M phase underwent steady dissolution by releasing Si and Ca ions into the SBF medium. After 7 days, a porous hydroxy-carbonate apatite (HCA) layer was formed at the SBF-glass ceramic interface. The micro-nanostructured apatite-wollastonite-2 M glass ceramics with improved mechanical properties, in comparison with the parent glass, could serve as a promising platform for hard tissue regeneration. |
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Keywords: | Simulated body fluid Glass ceramics Apatite Wollastonite-2 M Biomedical applications |
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