Prevention of breast cancer by dietary polyphenols—role of cancer stem cells |
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Authors: | Hao-Feng Gu Xue-Ying Mao |
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Affiliation: | 1. Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, China;2. College of Food Science &3. Nutritional Engineering, China Agricultural University, Beijing, China |
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Abstract: | AbstractBreast cancer is a common malignancy with poor prognosis. Cancer cells are heterogeneous and cancer stem cells (CSCs) are primarily responsible for tumor relapse, treatment-resistance and metastasis, so for breast cancer stem cells (BCSCs). Diets are known to be associated with carcinogenesis. Food-derived polyphenols are able to attenuate the formation and virulence of BCSCs, implying that these compounds and their analogs might be promising agents for preventing breast cancer. In the present review, we summarized the origin and surface markers of BCSCs and possible mechanisms responsible for the inhibitory effects of polyphenols on BCSCs. The suppressive effects of common dietary polyphenols against BCSCs, such as curcumin, epigallocatechin gallate (EGCG) and related polyphenolic compounds were further discussed. |
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Keywords: | Dietary polyphenols breast cancer stem cells mechanism differentiation proliferation |
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