超高效液相色谱-串联质谱法测定食品包装材料中全氟辛酸及其盐类物质

建立了超高效液相色谱-串联质谱(UPLC-MS/MS)结合加速溶剂萃取测定食品包装材料中全氟辛酸及其盐类物质(PFOA)的方法.采用甲醇作为溶剂,加速溶剂提取法提取食品包装材料中的PFOA,提取液经0.2 μm有机滤膜过滤后,以甲醇、水为流动相,梯度洗脱,经UPLC分离后用多级反应监测(MRM)方式测定.用两个子离子的...

Determination of Perfluorooctanoic Acid(PFOA)and its Salts in the Food Packaging Materials by UPLC/MS/MS

A method based on ultrahigh performance liquid chromatography tandem mass spectrometry(UPLC/MS/MS) with accelerated solvent extraction(ASE) was studied for quantitative detection of perfluorooctanoic acid(PFOA) and its salts in the food packaging materials.PFOA residue was extracted from the food packaging materials by UPLC using methanol/water as the mobile phase.PFOA was detective using electrospray ionization(ESI) on a tandem mass spectrometer in multiple reactions monitoring mode.Qualitative analysis of PFOA could be performed using the relative abundance of two daughter ions of PFOA,and quantitative analysis was conducted with the external standard method.The linear calibration curve was obtained in the range of 0.01～1.00μg/mL with a linear correlation coefficient(R2) of 0.999996.The recoveries for PFOA were 89.5 %～100.8% with relative standard deviations of 1.7%～3.2%.And the detection limit for PFOA was 0.1 μg/m2(S/N≥3).