Comparison of the effects of hypercholesterolaemia on relaxation responses in aortas of spontaneously hypertensive rats and Dahl salt-sensitive rats

1. We investigated the effects of hypercholesterolaemia on relaxation responses in thoracic aortas isolated from two different types of hypertensive rats; spontaneously hypertensive rats (SHR) and Dahl salt-sensitive rats (DSR). 2. All rats fed the high cholesterol diet for 8 weeks showed a significant increase in the serum cholesterol level. The high cholesterol diet did not change the blood pressure of SHR, but increased that of hypertensive DSR fed a high-salt diet. 3. In aortas of SHR, the high-cholesterol diet did not change the endothelium-dependent and -independent relaxation induced by acetylcholine (ACh) and sodium nitroprusside (SNP), respectively. 4. In aortas of hypertensive DSR, the high-cholesterol diet notably reduced the ACh-induced relaxations and slightly reduced SNP-induced relaxation. 5. These results suggest that hypercholesterolaemia causes greater impairment of endothelium-dependent relaxation in rat aorta with salt-induced hypertension than genetic hypertension.