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Cellular affinity of polyamides having various functional groups. I. Platelet adhesion
Authors:Naoya Ogata  Kohei Sanui  Hozumi Tanaka  Yoichi Takahashi  Yasuhisa Sakurai  Toshihiro Akaike  Teruo Okano  Kazunori Kataoka
Abstract:Various polyamides having a different density of hydrogen bonding, of hydrophilic character, and containing ionic groups have been synthesized and their blood compatibilities were evaluated in terms of the adhesion behavior of blood platelets on polyamide by the microsphere column method. Polyamides containing anionically charged groups such as carboxylate or sulfonate groups adsorbed fewer blood platelets than those with undissociated carboxylate groups. Polyamides having thioether groups adsorbed fewer platelets than those having ether groups. Introduction of a rigid piperazine unit caused an increase in platelet adhesion.
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