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Effect of crystallinity of condensation polymers on platelet adhesion
Authors:Naoya Ogata  Kohei Sanui  Hozumi Tanaka  Yoichi Takahashi  Eichi Kitamura  Yasuhisa Sakurai  Teruo Okano  Kazunori Kataoka  Toshihiro Akaike
Abstract:Various polyamides and polyesters having different numbers of methylene groups in their repeating units have been synthesized and their blood compatibilities have been evaluated in terms of the adhesion behavior of blood platelets on the surface of these condensation polymers by a micro-sphere-column method. The number of methylene groups in the repeating units of polyamides and polyesters influenced the adhesion behavior of platelets and there was an optimum number of methylene groups each in polyamides and polyesters. Poly(hexamethylene terephthalamide) and poly(pentamethylene terephthalate) adsorbed platelets in the smallest number in the polyamide and polyester series, respectively. Blood platelets were adsorbed on polyamides in smaller numbers than on corresponding polyesters. It was found that the platelet adhesion on the surface of polyamides and polyesters was closely related to their crystallinities and the number of the adsorbed platelets decreased linearly with increasing their relative crystallinity.
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