| N-甲基吡咯烷酮硫酸氢盐催化合成7-羟基-4-甲基香豆素 |
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| 引用本文： | 滕俊江,乔艳辉,林培喜.N-甲基吡咯烷酮硫酸氢盐催化合成7-羟基-4-甲基香豆素[J].化工进展,2012,31(6):1321-1324. |
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| 作者姓名： | 滕俊江 乔艳辉 林培喜 |
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| 作者单位： | 广东石油化工学院化学与生命科学学院，广东 茂名 525000 |
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| 基金项目： | 茂名市重点科技计划项目 |
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| 摘 要： | 以离子液体N-甲基吡咯烷酮硫酸氢盐为催化剂，通过Pechmann缩合反应于无溶剂条件下合成了7-羟基-4-甲基香豆素，实验表明N-甲基吡咯烷酮硫酸氢盐可重复使用并具有较好的催化活性。在原料摩尔比n(间苯二酚)∶n(乙酰乙酸乙酯)为1∶1.3、催化剂Hnmp]HSO4占反应物料总质量的1.2%、回流反应时间3 h的条件下，产品收率达87.24%，经液相色谱分析纯度大于98.5%。
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| 关 键 词： | N-甲基吡咯烷酮 硫酸氢盐 7-羟基-4-甲基香豆素 合成 |
Synthesis of 7-hydroxy-4-methylcoumarin catalyzed by 1-methyl-2-pyrrolidinone hydrosulfate |
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| TENG Junjiang,QIAO Yanhui,LIN Peixi.Synthesis of 7-hydroxy-4-methylcoumarin catalyzed by 1-methyl-2-pyrrolidinone hydrosulfate[J].Chemical Industry and Engineering Progress,2012,31(6):1321-1324. |
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| Authors: | TENG Junjiang QIAO Yanhui LIN Peixi |
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| Affiliation: | School of Chemistry and Life Science，Guangdong College of Petrochemical Technology， Maoming 525000，Guangdong，China |
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| Abstract: | 7-Hydroxy-4-methylcoumarin was synthesized by Pechmann reaction using ionic liquid 1-methyl-2-pyrrolidinone hydrosulfate as catalyst without solvent.The results showed that 1-methyl-2-pyrrolidinone hydrosulfate could be reused and exhibited excellent catalytic activity.Under the condition as:n(resorcinol)∶n(ethyl acetoacetate)=1∶1.3,1.2%(percent of total mass of reactants) HSO4,refluxing for 3 h,the yield of 7-hydroxy-4-methylcoumarin is up to 87.24%.Purity of product analyzed by HPLC is above 98.5%. |
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| Keywords: | 1-methyl-2-pyrrolidinone hydrosulfate 7-hydroxy-4-methylcoumarin synthesis |
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