Supplementation of prebiotics to a whey-based beverage reduces the risk of hypercholesterolaemia in rats |
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| Affiliation: | 1. Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro (IFRJ), Departamento de Alimentos, 20270–021 Rio de Janeiro, Brazil;2. Universidade do Estado do Rio de Janeiro (UERJ), Departamento de Química Analítica, 20550-013 Rio de Janeiro, Brazil;3. Instituto Federal do Paraná (IFPR), Paranavaí, 87703-536 Paraná, Brazil;4. Universidade Federal Fluminense (UFF), Faculdade de Medicina Veterinária, 24230-340 Niterói, Rio de Janeiro, Brazil;5. Empresa de Pesquisa Agropecuária de Minas Gerais (EPAMIG), Instituto de Laticínios Cândido Tostes (ILCT), 36045-560 Juiz de Fora, Minas Gerais, Brazil |
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| Abstract: | Fructooligosaccharide-supplemented whey drinks may have potential as an interventional strategy for lowering cholesterol and triglyceride levels in dyslipidaemic conditions. A bioefficacy study was conducted in normal, hypercholesterolaemic and hyperglycaemic Sprague Dawley rats, running two consecutive trials for validity of results. Control drink (T0), whey drink (T1) and whey drink supplemented with 1.5% fructooligosaccharides (T4), were given to each group. The functional drink caused a significant reduction in serum total cholesterol, low density lipoprotein (LDL) and triglycerides, and an increase in high density lipoprotein. The greatest decline in total cholesterol was induced by T4 (10.9% and 12.0% in hypercholesterolaemic rats and 7.0% and 7.7% in hyperglycaemic rats, for trials 1 and 2, respectively). The decrease in total cholesterol by T4 was mainly due to a pronounced decrease in LDL cholesterol (14.7% and 16.1% in hypercholesterolaemic rats and 7.4% and 8.1% in hyperglycaemic rats for trials 1 and 2, respectively). |
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