Differences in PARP Inhibitors for the Treatment of Ovarian Cancer: Mechanisms of Action,Pharmacology, Safety,and Efficacy |
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Authors: | Giorgio Valabrega Giulia Scotto Valentina Tuninetti Arianna Pani Francesco Scaglione |
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Affiliation: | 1.Department of Oncology, School of Medicine, University of Torino, 10124 Torino, Italy; (G.S.); (V.T.);2.Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy;3.Department of Oncology and Hemato-Oncology, School of Medicine, University of Milan, 20122 Milan, Italy; (A.P.); (F.S.) |
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Abstract: | Poly(ADP-ribose) polymerases (PARP) are proteins responsible for DNA damage detection and signal transduction. PARP inhibitors (PARPi) are able to interact with the binding site for PARP cofactor (NAD+) and trapping PARP on the DNA. In this way, they inhibit single-strand DNA damage repair. These drugs have been approved in recent years for the treatment of ovarian cancer. Although they share some similarities, from the point of view of the chemical structure and pharmacodynamic, pharmacokinetic properties, these drugs also have some substantial differences. These differences may underlie the different safety profiles and activity of PARPi. |
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Keywords: | ovarian cancer olaparib niraparib rucaparib safety efficacy |
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