Apoptosis Disorder,a Key Pathogenesis of HCMV-Related Diseases |
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| Authors: | Zhongjie Yu Yashuo Wang Lili Liu Xianjuan Zhang Shasha Jiang Bin Wang |
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| Affiliation: | 1.Department of Special Medicine, School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao 266000, China;2.College of Life Sciences, Qingdao University, Qingdao 266000, China;3.Department of Basic Medicine, School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao 266000, China;4.Department of Pathogenic Biology, School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao 266000, China; (X.Z.); (S.J.) |
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| Abstract: | Human cytomegalovirus (HCMV) belongs to the β-herpesvirus family, which is transmitted in almost every part of the world and is carried by more than 90% of the general population. Increasing evidence indicates that HCMV infection triggers numerous diseases by disrupting the normal physiological activity of host cells, particularly apoptosis. Apoptosis disorder plays a key role in the initiation and development of multiple diseases. However, the relationship and molecular mechanism of HCMV-related diseases and apoptosis have not yet been systematically summarized. This review aims to summarize the role of apoptosis in HCMV-related diseases and provide an insight into the molecular mechanism of apoptosis induced by HCMV infection. We summarize the literature on HCMV-related diseases and suggest novel strategies for HCMV treatment by regulating apoptosis. |
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| Keywords: | HCMV apoptosis molecular mechanism target therapy |
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