Studies on compounds of cancer chemoprevention: synthesis of some amides |
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| Authors: | ZL Yuan SP Xu |
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| Affiliation: | Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing. |
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| Abstract: | In search for cancer chemoprevention agents, seven new amide compounds have been synthesized. The structures have been determined based on spectral and chemical data. N-4-(ethoxycarbophenyl)-alpha-naphthamide and N-4-(ethoxycarbophenyl)-beta-naphthamide were shown to be 81% and 79% effective, respectively, for inducing different in HL-60 human promyelocytic leukemia cells at the concentration of 10(-5) mol/L in NBT tests. |
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