Polymeric siRNA delivery vectors: knocking down cancers with polymeric‐based gene delivery systems |
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| Authors: | Aditya Ardana Andrew K. Whittaker Nigel A.J. McMillan Kristofer J. Thurecht |
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| Affiliation: | 1. Australian Institute for Bioengineering and Nanotechnology and Centre for Advanced Imaging, The University of Queensland, St Lucia, Queensland, Australia;2. ARC Centre of Excellence in Convergent Bio‐Nano Science and Technology, The University of Queensland, St Lucia, Australia;3. School of Medical Science, Gold Coast campus, Griffith University, Australia |
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| Abstract: | One of the most promising routes for cancer therapy that has evolved over the previous decade is the use of small‐interfering RNA (siRNA) as a means of switching off genes that are responsible for tumour development. However, while siRNA and gene/antisense therapies provide alternatives to conventional chemotherapies, significant hurdles related to the delivery and efficacy of treatment must still be overcome before this technology can be used as an effective treatment for cancer and other diseases. This review highlights the issues associated with siRNA therapy in vivo, and describes the various approaches that are being explored using polymers as delivery vectors. In particular, the review focuses on targeted delivery as a means of improving efficacy of the gene therapy. © 2014 Society of Chemical Industry |
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| Keywords: | siRNA polymers macromolecules gene therapy dendrimers |
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